Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
[2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl bromide → 2-(2-Bromo-5-nitrophenyl)-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | [2'-(N-t-Butylsulfamoyl)biphenyl-4-yl]methyl bromide | HCID 15282100 | — |
| 반응물 | 2-(2-Bromo-5-nitrophenyl)-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 135720080 | — |
| 생성물 | 2-(2-Bromo-5-nitrophenyl)-4-[[2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 10077917 | 92% |
반응 단계
The alkylation of 2-(2-bromo-5-nitrophenyl)-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step A) with [2'-(N-t-butylsulfamoyl)-biphenyl-4-yl]methyl bromide (from Example 12, Step D) was carried out according to the procedure of Example 13, Step A, to give a 92% yield of the title compound as a yellow solid, mp 126°-128° C.; homogeneous by TLC in 98:2 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 642, 644 (M+1)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05411980 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-efaccb8a782d42b8af7303a45639d2b3 |
| 출처 메모 | uspto-grants-1995_05 |