Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Methylsulfonyl)phenylhydrazine hydrochloride → 6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Methylsulfonyl)phenylhydrazine hydrochloride | HCID 2735181 | — |
| 반응물 | 1-(6-Fluorobenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione | HCID 23285364 | — |
| 생성물 | 6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole | HCID 23285367 | 65% |
반응 단계
The procedure of Example 9 was repeated using 1-(6-fluorobenzothiazol-2-yl)-4,4-difluorobutane-1,3-dione and 4-methylsulfonylphenylhydrazine hydrochloride as the starting materials to obtain 6-fluoro-2-[1-(4-methylsulfonylphenyl)-3-difluoromethyl-1H-pyrazol-5-yl]benzothiazole (yield, 65%). NMR(DMSO-d6) δ: 3.30 (3H, s), 7.23 (1H, t, J=54.1 Hz), 7.38-7.46 (1H, m), 7.56 (1H, s), 7.83-7.88 (2H, m), 7.94-7.99 (1H, m), 8.05-8.13 (3H, m); mp 204-206° C. (ethanol)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06136831 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-7d206a4b9ae24742a7ac4427a8182c24 |
| 출처 메모 | uspto-grants-2000_10 |