Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium hydride → Ethyl 3-trifluoromethanesulfonyloxy-2-heptenoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1,1,1-Trifluoro-N-phenylmethanesulfonamide | HCID 68012 | — |
| 반응물 | Ethyl 3-oxoheptanoate | HCID 559036 | — |
| 반응물 | Diethylether hexane | HCID 21584099 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Diethylether water | HCID 21584184 | — |
| 생성물 | Ethyl 3-trifluoromethanesulfonyloxy-2-heptenoate | HCID 54561069 | — |
반응 단계
Ethyl 3-ketoheptanoate (2.07 g, 12 mmol) was dissolved in dimethylformamide (60 mL) under argon and sodium hydride (357 mg, 14.4 mmol) was added. After 30 minutes at room temperature the solid N-phenyltrifluoro-methanesulfonamide (Tetra. Letters, (1983), 24, 979) (4.97 g, 13.8 mmol) was added. The reaction was stirred for 2 hours, diluted with ether/water and the usual workup gave after chromatography with 5:95 ether/hexane 3.45 g (94%) of ethyl 3-trifluoromethanesulfonyloxy-2-heptenoate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05418250 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-1eeaf04cd8bc43fdbc3683d9c62006b0 |
| 출처 메모 | uspto-grants-1995_05 |