Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate → HCID 57135938, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-butyl (2R,3S)-6-oxo-2,3-diphenylmorpholine-4-carboxylate | HCID 981230 | — |
| 반응물 | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| 반응물 | 3-Cyclobutylbenzyl bromide | HCID 18352491 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 57135938 | HCID 57135938 | 54.1% |
반응 단계
According to example 81, 2.50 g of tert-butyl- (2R, 3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate (Aldrich) was alkylated with 1.59 g of 3-cyclobutylbenzyl bromide in 80 mL of anhydrous THF using 7.41 mL of 1M sodium bis(trimethylsilyl)amide in THF (Aldrich). The crude product was subjected to flash chromatography on 120 g of silica gel (8:2 hexane:EtOAc) and then recrystallization from EtOH-water to afford 1.90 g (54%) of tert-butyl (2R, 3S, 5S)-6-oxo-2,3-diphenyl-5-(3-cyclobutylbenzyl)-4-morpholinecarboxylate as a white powder, m.p. 145-147° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06140100 |
| 출처 데이터셋 | uspto-grants-2000_10 |
| ORD ID | ord-a0731c46a2c343749606ce782d6325e2 |
| 출처 메모 | uspto-grants-2000_10 |