Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cyclopropylamine → HCID 178420900, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cyclopropylamine | HCID 69828 | — |
| 반응물 | 6-Chloropurine | HCID 5359277 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | HCID 178420900 | HCID 178420900 | 153.1% |
반응 단계
A solution of 6-chloropurine (Aldrich Chemical Company, 4.23 g, 27 mmoles) and cyclopropylamine (Aldrich Chemical Company, 12.5 g, 22 mmoles) in MeOH (100 ml) was heated at 50° C. for 48 hours. The solvent was removed, and the crude product was purified on a silica gel column eluting with CHCl3 : 5% MeOH to obtain 5.90 g of a cream solid. This was recrystallized from MeOH to give two crops, 2.69 g and 1.16 g (81.4% total yield); mp. 237-240.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05420115 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-27390c5745b6406283dfff51a10e27a3 |
| 출처 메모 | uspto-grants-1995_05 |