Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Carbonyldiimidazole → 1-(1H-Imidazol-1-yl)methyl-8-(N-phenyl-(4-hydroxybutyl)amino)imidazo[1,5-a]pyrido[3,4-e]pyrazin-4(5H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 2,4-Dichloro-5-nitropyridine | HCID 12275765 | — |
| 반응물 | N-phenyl-4-hydroxybutylamine | HCID 13755485 | — |
| 반응물 | 2-(1H-imidazol-1-ylmethyl)-1H-imidazole | HCID 19358846 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 생성물 | 1-(1H-Imidazol-1-yl)methyl-8-(N-phenyl-(4-hydroxybutyl)amino)imidazo[1,5-a]pyrido[3,4-e]pyrazin-4(5H)-one | HCID 19809415 | — |
반응 단계
Treat 2,4-dichloro-5-nitropyridine with 2-((imidazol-1-yl)methyl)imidazole followed by reaction with N-phenyl-4-hydroxybutylamine, hydrogenation with palladium on carbon and cyclization with carbonyldiimidazole to provide the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05166344 |
| 출처 데이터셋 | uspto-grants-1992_11 |
| ORD ID | ord-9e8e1be975904a8fb62fd8d45ae4d625 |
| 출처 메모 | uspto-grants-1992_11 |