참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Ammonium Persulfate | HCID 62648 | — |
| 반응물 | (2-Chloro-4,5-difluorophenyl)(phenyl)methanone | HCID 704945 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 생성물 | 2-Chloro-4,5-difluorobenzoic acid | HCID 737171 | 80.8% |
반응 단계
8 g of ammonium peroxodisulfate are introduced into 5 g (19.8 mmol ) of 2-chloro-4,5-difluorobenzophenone and 20 g of glacial acetic acid and the mixture is heated at 90° C. (12 h). 100 g of 70% sulfuric acid are then added and the mixture is heated for 2 h at 150° C. Dilution with 200 g of water and filtration gives 3.1 g (16.0 mmol, 81%) of 2-chloro-4,5-difluorobenzoic acid (purity (GC) ca. 92%). Recrystallization from water gives 2.5 g of product melting at 104° C.-105° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05481032 |
|---|
| 출처 데이터셋 | uspto-grants-1996_01 |
|---|
| ORD ID | ord-57ce944fb97645a09a59dd154d8b1826 |
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| 출처 메모 | uspto-grants-1996_01 |
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