참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Lactonitrile | HCID 6572 | — |
| 반응물 | Diisopropylamine | HCID 7912 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 2-(Diisopropylamino)propionitrile | HCID 10997260 | 75% |
반응 단계
Anhydrous magnesium sulfate (12.04 g, 0.1 mol) was added to diisopropylamine (12.14 g, 0.12 mol), followed by lactonitrile (7.73 g of 92% aqueous solution, 0.1 mol) added all at once with stirring. The reaction mixture spontaneously warmed up to 51° C. It was left overnight at room temperature. Diethyl ether (50 ml) was added, and magnesium sulfate was filtered off and washed with ether (50 ml). The product was isolated by distillation, 11.57 g, 75% yield, bp 49°-50° C./0.1 mm Hg. 1H NMR CDCl3 δ ppm, 1.02 (d, J=6.5 Hz, 6H, CH3), 1.17 (d, J=6.5 Hz, 6H, CH3), 1.41 (d, J=6.5 Hz, 3H, CH3, 3.21 (sep, J=6.5 Hz, 2H,=CH) , 3.89 (q, J=6.5 Hz, 1H, CH) .
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05481038 |
|---|
| 출처 데이터셋 | uspto-grants-1996_01 |
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| ORD ID | ord-c47826333e954a139ba74d6485ed7449 |
|---|
| 출처 메모 | uspto-grants-1996_01 |
|---|
