Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → 2-Indancarboxylic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | ethyl 2,3-dihydro-1H-indene-2-carboxylate | HCID 15280733 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-Indancarboxylic Acid | HCID 575777 | 69.1% |
반응 단계
Dissolve 2-(carboethoxy)indan (6.49 g, 34.1 mmol) in ethanol (95%, 150 mL) and water (75 mL). Add potassium hydroxide (9.5 g, 0.17 mol) and stir at room temperature for 1 hour. Partition between water (150 mL) and ethyl ether (2×150 mL). Acidify the aqueous phase with hydrochloric acid to pH 1. Extract with methylene chloride (2×150 mL), dry (Na2SO4) and evaporate the solvent in vacuo to give 2-indancarboxylic acid as a tan solid (3.82 g, 69%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05486513 |
| 출처 데이터셋 | uspto-grants-1996_01 |
| ORD ID | ord-5cb05735dbee469f9bcbe56e1d9e3aa5 |
| 출처 메모 | uspto-grants-1996_01 |