참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Butyryl chloride | HCID 8855 | — |
| 반응물 | 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile | HCID 79256 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 1-Phenyl-4-cyano-5-(n-propylcarbonylamino)-pyrazole | HCID 18993707 | 50% |
반응 단계
6.8 ml (66 mmol) of butyryl chloride were added to a solution of 5.52 g (30 mmol) of 1-phenyl-4-cyano-5-aminopyrazole [known from J. Org. Chem. 21 (1956), 1240] in 70 ml of pyridine. The mixture was heated for 15 hours at 50° C. and then poured into 500 ml of 5% strength by weight aqueous hydrochloric acid. The product was extracted from the aqueous phase with methylene chloride and then isolated in a conventional manner. Yield: 50%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05486618 |
|---|
| 출처 데이터셋 | uspto-grants-1996_01 |
|---|
| ORD ID | ord-b4109847d1db4483bc446fb578ac9153 |
|---|
| 출처 메모 | uspto-grants-1996_01 |
|---|
