Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dicyclohexylamine → 1-Phenyl-4-cyano-5-(dicyclohexylaminosulfonylureido)pyrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dicyclohexylamine | HCID 7582 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Chlorosulfonyl isocyanate | HCID 70918 | — |
| 반응물 | 5-Amino-1-phenyl-1H-pyrazole-4-carbonitrile | HCID 79256 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Phenyl-4-cyano-5-(dicyclohexylaminosulfonylureido)pyrazole | HCID 18993711 | 87% |
반응 단계
4.4 ml (50 mmol) of chlorosulfonyl isocyanate were added to a solution of 9.2 g (50 mmol) of 1-phenyl-4-cyano-5-aminopyrazole in 100 ml of methylene chloride. Stirring was carried out for 30 minutes at about 20° C., after which a solution of 7.5 ml (60 mmol) of triethylamine and 10 ml (50 mmol) of dicyclohexylamine in 50 ml of methylene chloride was slowly added dropwise. After the end of the addition, stirring was continued for a further hour and hydrolysis was then carried out with 200 ml of water. The organic phase was separated off and was worked up in a conventional manner to give the product. Yield: 87%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05486618 |
| 출처 데이터셋 | uspto-grants-1996_01 |
| ORD ID | ord-892ac24930964938b65e8098dccb8a46 |
| 출처 메모 | uspto-grants-1996_01 |