Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethylformamide → N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2-Bromo-4,5-dimethoxybenzoic acid | HCID 222963 | — |
| 반응물 | 1-Ethyl-1H-pyrazol-5-amine | HCID 337310 | — |
| 촉매 | Cupric acetate | HCID 8895 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid | HCID 21217688 | 97.6% |
반응 단계
A mixture of 5-amino-1-ethylpyrazole (5.0 g, 45 mmol), 2-bromo-4,5-dimethoxybenzoic acid (11.76 g, 45 mmol), K2CO3 (6.21 g, 45 mmol), Cu(OAc)2 (0.8 g, 400 mmol) and DMF (125 ml) was refluxed overnight. The reaction mixture was cooled, poured into water and acidified with acetic acid. The resulting solid was collected by filtration and dried to afford 12.8 g (97%) of N-(1-ethylpyrazol-5-yl)-4,5-dimethoxyanthranilic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05488055 |
| 출처 데이터셋 | uspto-grants-1996_01 |
| ORD ID | ord-01dd962ca2fc4c3ea128f9d346a5bb17 |
| 출처 메모 | uspto-grants-1996_01 |