Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene → 5-[2-(2,5-Dimethoxyphenyl)ethinyl]-2-hydroxybenzoic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Methyl 5-Iodosalicylate | HCID 248910 | — |
| 반응물 | 2,5-Dimethoxyphenylacetylene | HCID 11094951 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Oxygen | HCID 977 | — |
| 생성물 | 5-[2-(2,5-Dimethoxyphenyl)ethinyl]-2-hydroxybenzoic acid methyl ester | HCID 15384006 | — |
반응 단계
Under argon atmosphere 240 mg of 2,5-dimethoxyphenylacetylene and 493 mg of methyl 5-iodosalicylate are dissolved in 20 ml of oxygen-free and dry benzene. The mixture is treated with 85 mg of tetrakis (triphenylphosphine)palladium, 20 mg of copper(I)iodide and 450 mg of triethylamine, stirred at room temperature overnight and then poured onto 100 ml of aqueous pH 7 buffer. After extraction with ethyl acetate and purification by chromatography on silicagel, 5-[2-(2,5-dimethoxyphenyl)ethinyl]-2-hydroxybenzoic acid methyl ester is obtained (colorless crystals of M.P. 105°-108°).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05488135 |
| 출처 데이터셋 | uspto-grants-1996_01 |
| ORD ID | ord-00b5aedde9b640c795ea84266ba6a003 |
| 출처 메모 | uspto-grants-1996_01 |