Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-bromobutanimide → 5-(4'-bromomethylbiphenyl-2-yl)-1-(4-nitrophenyl)-1H-tetrazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | 5-(4'-Methyl[1,1'-biphenyl]-2-yl)-1-(4-nitrophenyl)-1H-tetrazole | HCID 19935776 | — |
| 촉매 | Azobisisobutyronitrile | HCID 6547 | — |
| 용매 | 1,1,1-Trichloroethane | HCID 6278 | — |
| 생성물 | 5-(4'-bromomethylbiphenyl-2-yl)-1-(4-nitrophenyl)-1H-tetrazole | HCID 19935791 | 79.7% |
반응 단계
A mixture of compound D (8.0 g; 21 mmol), N-bromosuccinimide (4.53 g; 25 mmol) and azo(bisisobutyronitrile) (73 mg) in methyl chloroform (50 ml) was heated at reflux for 4 hours. The mixture was cooled to ambient temperature, washed with water (3×50 ml), and the suspended solid collected by filtration to give 5-(4'-bromomethylbiphenyl-2-yl)-1-(4-nitrophenyl)-1H-tetrazole (E) (7.3 g), m.p 192°-195° C.; NMR (CDCl3): 4.4(2H, s), 6.52(2H, d), 6.85(2H, d), 7.07(2H, d), 7.4(1H, d), 7.7(2H, m), 7.9(1H, d).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05420292 |
| 출처 데이터셋 | uspto-grants-1995_05 |
| ORD ID | ord-df9997b1aa1e4db888a9ab3bcd42ebcb |
| 출처 메모 | uspto-grants-1995_05 |