Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 3-iodo-4-methoxybenzoate → Methyl 4-methoxy-3-(trifluoromethyl)benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 3-iodo-4-methoxybenzoate | HCID 316980 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | Potassium trifluoroacetate | HCID 23662811 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 4-methoxy-3-(trifluoromethyl)benzoate | HCID 19360538 | 77.1% |
반응 단계
9.7 g of methyl 3-iodo-4-methoxybenzoate, 9.4 g of potassium trifluoroacetate and 12.9 g of copper(I) iodide were heated at 160° C. for 5 h in 250 ml of DMF. The mixture was poured onto 500 ml of NaHCO3 solution, the precipitate which was deposited was filtered off and both the precipitate and the aqueous phase were extracted with ethyl acetate. The combined organic phases were concentrated, and the residue was purified by flash chromatography using hexane/ethyl acetate 3:1. 6 g of methyl 3-trifluoromethyl-4-methoxybenzoate were obtained;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06022899 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-ab883e27785d4e938aaa7604c6c30865 |
| 출처 메모 | uspto-grants-2000_02 |