참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Glycine | HCID 750 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Benzoyl chloride, 3-nitro- | HCID 8495 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Glycine, N-(3-nitrobenzoyl)- | HCID 94858 | 90% |
반응 단계
Glycine (20 g, 266 mmol) was added to water (200 mL), followed by potassium hydroxide (20 g, 357 mmol) and cooled to 0° C. in an ice bath. To this solution was added 3-nitrobenzoyl chloride (20 g, 108 mmol) in acetonitrile (20 mL) drop-wise over a 10 minute period. After the reaction was complete (3-4 hours) concentrated hydrochloric acid was added until pH=2 followed by saturated aqueous NaCl (75 mL). The product was filtered, washed with water and air dried (22 g, 90% yield). 1H-NMR (d6 -DMSO) δ 3.92 (d, 2H, J=6.1), 7.9 (t, 1H, J=7.9), 8.3 (t, 1H, J=5.6), 8.35 (m, 2H), 8.69 (s, 1H), 9.25 (t, 1H, J=7.2 Hz).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06028223 |
|---|
| 출처 데이터셋 | uspto-grants-2000_02 |
|---|
| ORD ID | ord-6437b511a083456b9ca417d762df1447 |
|---|
| 출처 메모 | uspto-grants-2000_02 |
|---|
