Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Dimethylaminopyridine → Ethyl beta-[[2-[[(3-nitrophenyl)carbonyl]amino]acetyl]amino]pyridine-3-propanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Dimethylaminopyridine | HCID 21885 | — |
| 반응물 | Glycine, N-(3-nitrobenzoyl)- | HCID 94858 | — |
| 반응물 | Di(succinimido) carbonate | HCID 676246 | — |
| 반응물 | 3-(Ethylamino)propanoic acid hydrochloride | HCID 86759576 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Potassium Carbonate | HCID 11430 | — |
| 생성물 | Ethyl beta-[[2-[[(3-nitrophenyl)carbonyl]amino]acetyl]amino]pyridine-3-propanoate | HCID 22608595 | 80% |
반응 단계
The same procedure used in the preparation of Example C was followed substituting an equivalent amount of DL-ethyl 3-amino-3-pyridyl propionate for ethyl beta-alanine hydrochloride. N,N'-Disuccinimidyl carbonate (14 g, 5.5 mmol) was added to 3-nitro-benzoyl glycine (10 g, 4.5 mmol) in dry dimethylformamide (30 mL) followed by dimethylaminopyridine (200 mg). After a period of 1 hour DL-ethyl 3-amino-3-(3-pyridyl) propionate dihydrochloride (13 g, 4.6 mmol) in 20% aqueous potassium carbonate (50 mL) was added in one portion. After complete reaction the product was collected by filtration (11.5 g, 80% yield). MS and 1H-NMR were consistent with the proposed structure.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06028223 |
| 출처 데이터셋 | uspto-grants-2000_02 |
| ORD ID | ord-b5d2c8a532754646add25af6990ac224 |
| 출처 메모 | uspto-grants-2000_02 |