Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-[4-(4-Chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | Thiourea | HCID 2723790 | — |
| 반응물 | 4-Chlorobenzyl-4-(3-chloropropyl)piperazine dihydrochloride | HCID 20153189 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 3-[4-(4-Chlorobenzyl)piperazin-1-yl]propanethiol dihydrochloride | HCID 13731118 | 75% |
반응 단계
Utilizing the procedure described in Example 1(b), 6.0 g of thiourea, was reacted with 25.2 g of 1-(4-chlorobenzyl-4-(3-chloropropyl)piperazine dihydrochloride and 8.7 g of triethylamine in 200 ml of reagent ethanol. The hydrolysis was effected with 5.0 g of sodium hydroxide in 50 ml of water. Work-up as described above gave 16.6 g (75% of theory) of 3-[4-(4-chlorobenzyl)piperazine-1-yl]propanethiol dihydrochloride as an off-white crystalline solid, M.p. 257°-260° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04722926 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-dd78e8a69cf04d3fa6ac7e292bbcdfdd |
| 출처 메모 | uspto-grants-1988_02 |