Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 380002생성일: 2026년 10월 24일
Sodium Carbonate → (1S,2R)-3-Chloro-4'-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)biphenyl-4-carbonitrile
https://huagongshe.com/ko/reaction/380002
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Bromo-2-chlorobenzonitrile | HCID 7010420 | — |
| 반응물 | (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid | HCID 54413593 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (1S,2R)-3-Chloro-4'-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)biphenyl-4-carbonitrile | HCID 57191772 | 69% |
반응 단계
Prepared according to the method described in Example 12b) from (1S,2R)-4-(2-hydroxy-1-methyl-4-pyridin-3-ylbutoxy)benzeneboronic acid (0.20 g, Example 33), 4-bromo-2-chlorobenzonitrile (0.288 g), 2M aqueous sodium carbonate (0.76 ml) and tetrakis(triphenylphosphine)palladium (0) (0.075 g) in ethanol (5 ml) with heating at 90° C. for 4 hours. After work up, the residue was purified by normal-phase HPLC eluting with a gradient of 0-10% ethanol in dichloromethane to give the title compound as an oil (0.18 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06300352B1 |
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| 출처 데이터셋 | uspto-grants-2001_10 |
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| ORD ID | ord-1e795bac0e8943e7ad5ad9d9ee0d679e |
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| 출처 메모 | uspto-grants-2001_10 |
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