Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(Pyrimidin-5-yl)boronic acid → (1E,4E)-ethyl 2-amino-8-(pyrimidin-5-yl)-3H-benzo[b]azepine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (Pyrimidin-5-yl)boronic acid | HCID 2795193 | — |
| 반응물 | ethyl 2-amino-8-bromo-3H-benzo[b]azepine-4-carboxylate | HCID 58228535 | — |
| 생성물 | (1E,4E)-ethyl 2-amino-8-(pyrimidin-5-yl)-3H-benzo[b]azepine-4-carboxylate | HCID 51034072 | — |
반응 단계
The title compound was prepared by the procedure as described in Example 124 (Step F) using (1E,4E)-ethyl 2-amino-8-bromo-3H-benzo[b]azepine-4-carboxylate and pyrimidin-5-ylboronic acid. MS APCI (+) m/z 309 (M+1) detected; 1H-NMR (400 MHz, CDCl3) δ 9.22 (s, 1H), 9.02 (s, 2H), 7.84 (s, 1H), 7.54 (d, 1H), 7.47 (d, 1H), 7.30 (dd, 1H), 4.34 (q, 2H), 2.99 (s, 2H), 1.40 (t, 3H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524702B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-14386f9cc3ad406cb10a4186c7502bea |
| 출처 메모 | uspto-grants-2013_09 |