Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 38145생성일: 2026년 10월 24일
Phthaloyl chloride → (Tert-butoxy)-n-[2-(1,3-dioxobenzo[c]azolidin-2-yl)pyrimidin-5-yl]carboxamide
https://huagongshe.com/ko/reaction/38145
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phthaloyl chloride | HCID 6955 | — |
| 반응물 | tert-Butyl (2-aminopyrimidin-5-yl)carbamate | HCID 22064425 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (Tert-butoxy)-n-[2-(1,3-dioxobenzo[c]azolidin-2-yl)pyrimidin-5-yl]carboxamide | HCID 20800274 | 91.1% |
반응 단계
To a solution of N-(2-aminopyrimidin-5-yl)(tert-butoxy)carboxamide (0.237 g, 1.0 mmol) in pyridine (1 mL) was added phthaloyl dichloride (0.144 mL, 1.0 mmol). The resulting suspension was stirred at 45° C. for 2 hr, diluted with EtOAc, washed with water and brine, dried and concentrated in vacuo to give crude (tert-butoxy)-N-[2-(1,3-dioxobenzo[c]azolidin-2-yl)pyrimidin-5-yl]carboxamide (0.31 g). ES-MS (M+H)+=341; (M+H-tBu)+=285.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08524721B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-6d84e0d607b74e3cbcd1f84777651352 |
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| 출처 메모 | uspto-grants-2013_09 |
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