Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl 4-amino-5-chloro-2-methoxybenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 반응물 | 4-Amino-5-chloro-2-methoxybenzoic acid | HCID 81626 | — |
| 생성물 | Methyl 4-amino-5-chloro-2-methoxybenzoate | HCID 700493 | — |
반응 단계
To a solution of 4-amino-5-chloro-2-methoxybenzoic acid (20.0 g, 99.2 mmol) in methanol (250 mL) was added thionyl chloride (7.2 mL, 99.2 mmol). The reaction was refluxed for 16 h then concentrated in vacuo. Purification by silica gel chromatography (0-90% ethyl acetate/hexanes) provided methyl 4-amino-5-chloro-2-methoxybenzoate (21.3 g, quantitative yield). LC/MS m/z 216.3 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367660B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-c854b6fe5af44a9c93661e851951073b |
| 출처 메모 | uspto-grants-2013_02 |