Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → 4-[4-(Benzyloxy)butoxy]-6-(trifluoromethyl)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | Diisopropyl diazene-1,2-dicarboxylate | HCID 75555 | — |
| 반응물 | 4-Benzyloxy-1-butanol | HCID 562212 | — |
| 반응물 | HCID 178516143 | HCID 178516143 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[4-(Benzyloxy)butoxy]-6-(trifluoromethyl)pyrimidine | HCID 59527261 | 52.1% |
반응 단계
To a solution of 4-(benzyloxy)butan-1-ol (3.00 g), 6-(trifluoromethyl)pyrimidin-4-ol (3.00 g), and triphenylphosphine (5.25 g) in THF (30 mL) was added diisopropyl azodicarboxylate (4.05 g), and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=9/1) to obtain 4-[4-(benzyloxy)butoxy]-6-(trifluoromethyl)pyrimidine (2.83 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08367702B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-456c051eee1c446ea8710e55bc88f3cb |
| 출처 메모 | uspto-grants-2013_02 |