참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-Amino-3-chloropyrazine-2-carbonitrile | HCID 21075392 | — |
| 반응물 | Sodium methanolate methanol | HCID 23694274 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-Amino-3-methoxypyrazine-2-carbonitrile | HCID 59613384 | 58% |
반응 단계
5-Amino-3-chloropyrazine-2-carbonitrile (52 mg, 0.34 mmol) was suspended in NaOMe/MeOH (2M, 2 mL). The reaction mixture was heated at 80° C. for 30 min using microwave irradiation. After cooling, the mixture was diluted with MeOH (3 mL) and water (2 mL). The solvents were concentrated and the resulting precipitate was filtered off, washed with water (3 mL) and dried in vacuo to give the title compound as a yellow solid (33 mg, 58%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08367658B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-3f89ef85d9d14031bdc39093f3e5c7a0 |
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| 출처 메모 | uspto-grants-2013_02 |
|---|
