Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(5,6,7,8-Tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol → 3-[(7-{(2E)-4-[Methyl(1-methylethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)amino]phenol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(5,6,7,8-Tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol | HCID 58116796 | — |
| 반응물 | (2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride | HCID 86650197 | — |
| 생성물 | 3-[(7-{(2E)-4-[Methyl(1-methylethyl)amino]but-2-enoyl}-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4-yl)amino]phenol | HCID 25222664 | — |
반응 단계
In analogy to Example 89, the title compound was prepared from 3-(5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-ylamino)phenol from Example 16A (100 mg, 0.25 mmol) and (2E)-4-[methyl(1-methylethyl)amino]but-2-enoic acid hydrochloride from Example 2A (68 mg, 0.35 mmol) to yield 35 mg (31%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524722B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-9687d916e08f4715810cf6a3e104cb1e |
| 출처 메모 | uspto-grants-2013_09 |