Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Bromocrotonic acid → HCID 58116851, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Bromocrotonic acid | HCID 6436411 | — |
| 반응물 | 1,4-Oxazepane hydrochloride | HCID 23090214 | — |
| 반응물 | N-[1-(Pyridin-2-ylmethyl)-1H-indazol-5-yl]-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]-pyrimidin-4-amine | HCID 58116989 | — |
| 생성물 | HCID 58116851 | HCID 58116851 | — |
반응 단계
The title compound was synthesized in analogy to Example 130 from N-[1-(pyridin-2-ylmethyl)-1H-indazol-5-yl]-5,6,7,8-tetrahydropyrido[4′,3′:4,5]thieno[2,3-d]pyrimidin-4-amine from Example 62A (100 mg, 0.24 mmol), (2E)-4-bromobut-2-enoic acid (75 mg, 0.36 mmol) and 1,4-oxazepane hydrochloride (53 mg, 0.39 mmol) to yield 62 mg (42%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524722B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-2de62650b62f44719b85b8618e0f7ac0 |
| 출처 메모 | uspto-grants-2013_09 |