Triethylamine → HCID 86649730, 화합물

HRID 386758

반응식

HRID 386758 반응식
[Br:1][C:2]1[CH:31]=[CH:30][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]([C:14]([NH:16][CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])=[O:15])=[C:10]([OH:25])[C:9]3[CH2:26][NH:27][CH:28]([CH3:29])[C:8]2=3)=[CH:4][CH:3]=1.Cl.C1(C2C=CC=CC=2)C=CC(CN2C(=O)C(C(NCC(OC(C)(C)C)=O)=O)=C(O)C3CNCC2=3)=CC=1.[S:68]1[CH:72]=[C:71]([C:73](Cl)=[O:74])[N:70]=[CH:69]1.CCN(CC)CC>CCOC(C)=O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:12](=[O:13])[C:11]([C:14]([NH:16][CH2:17][C:18]([O:20][C:21]([CH3:23])([CH3:24])[CH3:22])=[O:19])=[O:15])=[C:10]([OH:25])[C:9]3[CH2:26][N:27]([C:73]([C:71]4[N:70]=[CH:69][S:68][CH:72]=4)=[O:74])[CH:28]([CH3:29])[C:8]2=3)=[CH:30][CH:31]=1

참가 물질

6

반응물 4

HCID 8471TriethylamineHCID 155721001,3-Thiazole-4-carbonyl chlorideHCID 66850853HCID 66850853, 화합물HCID 71251569HCID 71251569, 화합물

생성물 1

HCID 86649730HCID 86649730, 화합물

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

To tert-butyl N-{[1-(4-bromobenzyl)-4-hydroxy-7-methyl-2-oxo-2,5,6,7-tetrahydro-1H-pyrrolo[3,4-b]pyridin-3-yl]carbonyl}glycinate (1.344 g, 2.73 mmol, prepared in similar fashion to Intermediate 6 utilizing the appropriate starting materials) was added the product of Step A (0.403 g, 2.73 mmol) and NEt3 (0.38 mL, 2.73 mL). The reaction stirred at rt for about 17 h and was then diluted with EtOAc and washed with aq Na2CO3 (2 M) and brine. The concentrated residue was purified by flash chromatography on silica gel gradient eluted with 0-65% EtOAc/hexane to afford the product.

후처리

  1. washwashed with aq Na2CO3 (2 M) and brine
  2. customThe concentrated residue was purified by flash chromatography on silica gel gradient
  3. washeluted with 0-65% EtOAc/hexane
  4. customto afford the product

출처 및 근거

ORD 기록
ord-cbf17ac683f7465ea5188d892c0f1c8b
출처 데이터셋
uspto-grants-2013_02
특허 번호
US08372863B2

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