Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Hydroxide → (S)-(7-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 5-Bromo-2-[(2R)-oxiran-2-ylmethoxy]phenyl formate | HCID 54148805 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (S)-(7-Bromo-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)methanol | HCID 23394142 | — |
반응 단계
Preparation according to Preparation 8 using 5-bromo-2-[(2R)-oxiran-2-ylmethoxy]phenyl formate (7.0 g, 25 mmol), dioxane (30 ml) and KOH (10%, 15 ml), stirred for 1 h. Purification on flash column chromatography (Isooctane/EtOAc). Crude yield: 3.7 g. MS m/z (rel. intensity, 70 eV) 245 (M+, 97) 244 (M+, bp), 189 (48), 188 (50) 79 (39).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08524766B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-e8b8ba4163e34860aa156c4fc4e5c70d |
| 출처 메모 | uspto-grants-2013_09 |