Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonyl chloride → N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)methanesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonyl chloride | HCID 31297 | — |
| 반응물 | N1-(6-chloro-4-iodopyridin-2-yl)cyclohexane-1,3-diamine | HCID 86649873 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | N-(3-(6-chloro-4-iodopyridin-2-ylamino)cyclohexyl)methanesulfonamide | HCID 87178324 | — |
반응 단계
To a solution of EXAMPLE 11A (100 mg, 0.3 mmol) in pyridine (5 mL) was added methanesulfonyl chloride (50 mg, 0.4 mmol). The mixture was stirred at ambient temperature for 5 h and partitioned between ethyl acetate and brine. The organic phase was washed with brine and concentrated. The residue was purified by flash chromatography on silica gel eluting with ethyl acetate to provide the title compound. Yield: 100 mg (82%). MS (DCI/NH3) m/z 430 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383624B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-9a914a045aa04c59866671a9903bff04 |
| 출처 메모 | uspto-grants-2013_02 |