Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 3-(5-Fluoropyridin-3-yl)-5-(pyridin-3-yl)isoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | 3-Ethynylpyridine | HCID 186003 | — |
| 반응물 | 5-Fluoro-N-hydroxynicotinimidoyl chloride | HCID 86636846 | — |
| 생성물 | 3-(5-Fluoropyridin-3-yl)-5-(pyridin-3-yl)isoxazole | HCID 69006240 | — |
반응 단계
The titled compound was prepared according to Method CB using the product of Example 28B (88 mg, 0.5 mmol) and 3-ethynylpyridine (Aldrich, 52 mg, 0.5 mmol). 1H NMR (300 MHz, MeOH-d4) 87.59 (s, 1H), 7.63 (ddd, J=8.0, 5.1, 0.8 Hz, 1H), 8.19 (ddd, J=9.3, 2.8, 1.8 Hz, 1H), 8.36 (dt, J=7.9, 2.0 Hz, 1H), 8.62 (d, J=2.8 Hz, 1H), 8.68 (dd, J=5.2, 1.6 Hz, 1H), 8.99 (t, J=1.6 Hz, 1H), 9.12 (d, J=2.4 Hz, 1H) ppm; MS (DCI/NH3) m/z 242 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383658B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-1e314d494b214b1bb5913b2d90e608e3 |
| 출처 메모 | uspto-grants-2013_02 |