Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → Hydrochloric Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 반응물 | 1-(tert-Butoxycarbonyl)-4-piperidinecarboxylic acid | HCID 392871 | — |
| 반응물 | Methylamine hydrochloride | HCID 6364545 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Hydrochloric Acid | HCID 313 | — |
| 생성물 | N-methylpiperidine-4-carboxamide | HCID 2760460 | — |
반응 단계
To a stirring solution of BOC-isonipecotic acid (400 mg) in N,N-dimethylformamide (4 mL) was added 1,1′-carbonyldiimidazole (560 mg). The reaction mixture was stirred overnight and then methylamine hydrochloride (280 mg) and triethylamine (0.48 mL) were added. After 5 hours the reaction mixture was diluted with ethyl acetate, washed with water, dried (MgSO4) and the solvent removed in vacuo. Treatment with HCl yielded piperidine-4-carboxylic acid methylamide, which was isolated as the hydrochloride salt.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383620B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-a70916512f6146d395d309e2ba3bcdd5 |
| 출처 메모 | uspto-grants-2013_02 |