Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanesulfonylmethanesulfonyl chloride → HCID 87209439, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanesulfonylmethanesulfonyl chloride | HCID 556269 | — |
| 반응물 | 4-(2-Chloro-6-(piperazin-1-ylmethyl)thieno[3,2-d]pyrimidin-4-yl)morpholine | HCID 57494057 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | HCID 87209439 | HCID 87209439 | — |
반응 단계
To 2-chloro-4-morpholino-6-((piperazin-1-yl)methyl)thieno[3,2-d]pyrimidine (54 mg) in DCM (2 ml) and triethylamine (44 ul) was added methylsulfonylmethylsulfonyl chloride (45 ul) at 0° C. The reaction mixture was allowed to warm up to room temperature overnight. Aqueous work-up and purification on silica gave 2-chloro-6-(4-methanesulfonylmethanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (35 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383620B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-42285cce3d3f471088bc7a474a53cf9f |
| 출처 메모 | uspto-grants-2013_02 |