참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methanesulfonamide | HCID 72879 | — |
| 반응물 | Cyclopropanecarboxaldehyde | HCID 123114 | — |
| 촉매 | Titanium isopropoxide | HCID 11026 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | N-(cyclopropylmethylene)methanesulfonamide | HCID 66788560 | — |
반응 단계
To a solution of cyclopropanecarbaldehyde (0.374 mL, 5 mmol) and methanesulfonamide (0.523 g, 5.5 mmol) in toluene (15 mL) was added titanium(IV) isopropoxide (2.93 mL, 10 mmol), and the mixture was heated to 100° C. for 1 day. The mixture was cooled to room temperature and concentrated in vacuo. The residue was placed under high vacuum for 30 min to give a biphasic mixture. The top layer was discarded. The residue was used in next step without further purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08383827B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_02 |
|---|
| ORD ID | ord-897fb256a2e34a17bf3f9cbbdceb3a8a |
|---|
| 출처 메모 | uspto-grants-2013_02 |
|---|
