Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide → methyl{3-[N-({5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]phenyl}acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide | HCID 57657904 | — |
| 반응물 | Methyl (3-{N-[(5-bromopyridin-3-yl)carbonyl]-S-methylsulfonimidoyl}phenyl)acetate | HCID 57657931 | — |
| 생성물 | methyl{3-[N-({5-[(3-{[(1,3-dimethyl-1H-pyrazol-5-yl)carbonyl]amino}phenyl)ethynyl]pyridin-3-yl}carbonyl)-S-methylsulfonimidoyl]phenyl}acetate | HCID 57657926 | — |
반응 단계
In a manner similar to that described in Example 460, methyl (3-{N-[(5-bromopyridin-3-yl)carbonyl]-S-methylsulfonimidoyl}phenyl)acetate (202 mg, 0.492 mmol) and N-(3-ethynylphenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide (153 mg, 0.64 mmol), were converted to the title compound as a light yellow solid foam (275 mg, 98%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383825B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-0e0b99c3d076441f885ed4bac8624917 |
| 출처 메모 | uspto-grants-2013_02 |