Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminobenzyl alcohol → HCID 57474716, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminobenzyl alcohol | HCID 21439 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | HCID 57474573 | HCID 57474573 | — |
| 반응물 | HCID 57474717 | HCID 57474717 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 57474716 | HCID 57474716 | 86% |
반응 단계
Ethyl 5-nitro-2-(2-(hydroxymethyl)phenylamino)-6-(2-methoxyphenylamino)pyrimidine-4-carboxylate. Ethyl 2-chloro-6-(2-methoxyphenylamino)-5-nitropyrimidine-4-carboxylate (See Example 30.A) (0.300 g, 0.852 mmol), 2-aminobenzyl alcohol (0.125 g, 1.2 mmol) and diisopropylethylamine (0.296 g) were reacted according to General Procedure C, except at room temperature and in dimethylformamide (5 ml). The crude reaction mixture was condensed and purified using Biotage chromatography (60 to 100% EtOAc in hexanes) to afford the title compound (0.323 g, 86%). MS (ESI) m/z 440.5 [M+1]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383634B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-0f74feac840e4890ab527f36cd025e46 |
| 출처 메모 | uspto-grants-2013_02 |