Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → [4-(3,4-Dichloro-benzyloxy)-phenyl]-oxo-acetaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Hydroxyphenylglyoxal | HCID 90568 | — |
| 반응물 | 4-(Bromomethyl)-1,2-dichlorobenzene | HCID 639726 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | [4-(3,4-Dichloro-benzyloxy)-phenyl]-oxo-acetaldehyde | HCID 86654900 | 84.1% |
반응 단계
To a solution of (4-hydroxy-phenyl)-oxo-acetaldehyde (756 mg) in dry DMF (10 mL) were added 3,4-dichlorobenzylbromide (1.2 g) and potassium carbonate (1.03 g). After 4 hours, the reaction mixture was poured into water (100 mL) and extracted with ethyl acetate (2×50 mL). The organic extracts were then combined and washed with brine (2×50 mL) and a saturated sodium bicarbonate solution (2×50 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure to give [4-(3,4-dichloro-benzyloxy)-phenyl]-oxo-acetaldehyde (1.3 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08383644B2 |
| 출처 데이터셋 | uspto-grants-2013_02 |
| ORD ID | ord-190e1298460940999e520fe963dbd425 |
| 출처 메모 | uspto-grants-2013_02 |