Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Chloro-1,1,1-triethoxyethane → 2-(Chloromethyl)-[1,3]thiazolo[5,4-b]pyridine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Chloro-1,1,1-triethoxyethane | HCID 305922 | — |
| 반응물 | HCID 178418545 | HCID 178418545 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2-(Chloromethyl)-[1,3]thiazolo[5,4-b]pyridine | HCID 14204207 | — |
반응 단계
A mixture of 3-amino-2-mercaptopyridine (3.6 g) prepared by the method of J. Org. Chem., 29, 2652 (1963), 2-chloro-1,1,1-triethoxyethane (6.5 g) and ethanol (60 ml) was heated at 60° C. for 4 hours. The crude solid resulting from evaporation of ethanol was chromatographed over silica gel to obtain the product (2.94 g; m.p. 71°-73° C.).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04723010 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-a0090fb00f2643b09c4adc1174b6350e |
| 출처 메모 | uspto-grants-1988_02 |