참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Stannous Chloride | HCID 24479 | — |
| 반응물 | 2-Chloro-5-nitrobenzophenone | HCID 118591 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (5-Amino-2-chlorophenyl)(phenyl)methanone | HCID 10489713 | — |
반응 단계
2-Chloro-5-nitrobenzophenone (1.3 g,5.0 mmol), tin(II) chloride (4.5 g, 20 mmol), and ethanol (20 ml) were mixed and heated at 70° C. for 1 h. After cooling to room temperature, to the reaction mixture were added ice, EtOAc and aqueous NaHCO3 and it was stirred for 30 min. The organic layer was washed with brine and dried over MgSO4. Filtration and evaporation afforded 5-amino-2-Chlorobenzophenone. 1H NMR, 7.85(m,2H), 7.30-7.66 (m,3H7.20 (d,1H,J=8.8 Hz), 6.60-6.80 (m,2H). MS calcd 231.1; MS (M+1) 232.0.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06800651B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_10 |
|---|
| ORD ID | ord-e1b29d11510c40008c7c6efbe6135613 |
|---|
| 출처 메모 | uspto-grants-2004_10 |
|---|
