Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 4-[2-[[7-Chloro-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2-yl]amino]ethyl]-benzenesulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 4-(2-Aminoethyl)benzenesulfonamide | HCID 169682 | — |
| 반응물 | 5-(Benzylthio)-2-bromo-7-chlorothiazolo[4,5-d]pyrimidine | HCID 22052038 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 4-[2-[[7-Chloro-5-[(phenylmethyl)thio]thiazolo[4,5-d]pyrimidin-2-yl]amino]ethyl]-benzenesulfonamide | HCID 22649015 | 78.4% |
반응 단계
A solution of the product from Example 219 (0.3 g) in tetrahydrofuran (2 ml) containing 4-(2-aminoethyl)benzenesulfonamide (0.161 g) and N-ethyldiisopropylamine (0.5 ml) was stirred for 16 hours. The mixture was evaporated to dryness then purified (SiO2, ethyl acetate:dichloromethane 4:6 as eluant) to give the title compound (310 mg).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06806273B1 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-3c51001c0d2447609ac10a00ff064941 |
| 출처 메모 | uspto-grants-2004_10 |