참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | m-Toluidine | HCID 7934 | — |
| 반응물 | Diethyl (ethoxymethyl)malonate | HCID 98702 | — |
| 용매 | 1,1'-Biphenyl, mixt. with 1,1'-oxybis(benzene) | HCID 24670 | — |
| 생성물 | Ethyl 7-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate | HCID 178469524 | 76.3% |
반응 단계
Diethyl ethoxymethylmalonate (37.8 mL, 187 mmol) and m-toluidine (20.0 mL, 187 mmol) were combined and heated at 100° C. for about 3 hours. The reaction mixture was allowed to cool to ambient temperature and it solidified. Dowtherm A (350 mL) was added and the reaction mixture was heated at reflux for about 30 minutes. The reaction mixture was allowed to cool to ambient temperature. The resulting precipitate was isolated by filtration, rinsed with acetone and dried to provide 33 g of ethyl 4-hydroxy-7-methyl-3-quinolinecarboxylate as a tan powder.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06809203B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_10 |
|---|
| ORD ID | ord-409dc54188c142688eb537344e936c84 |
|---|
| 출처 메모 | uspto-grants-2004_10 |
|---|
