Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl 3-(aminomethyl)pyrrolidine-1-carboxylate → (2R)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-N-(3-pyrrolidylmethyl)pyrrolidine-2-carboxamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl 3-(aminomethyl)pyrrolidine-1-carboxylate | HCID 2756485 | — |
| 반응물 | (1-Benzylpyrrolidin-3-yl)methanol | HCID 5176654 | — |
| 반응물 | (2R)-1-{(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonylpyrrolidine-2-carboxylic acid | HCID 69100730 | — |
| 생성물 | (2R)-1-{(2S,4R)-4-hydroxy-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-N-(3-pyrrolidylmethyl)pyrrolidine-2-carboxamide | HCID 69101451 | — |
반응 단계
The title compound was prepared by successively conducting procedures similar to Step 5 of Example 1 and Example 46, using 3-aminomethyl-1-(t-butoxycarbonyl)pyrrolidine [which was synthesized by a method similar to the one described in Japan Kokai Hei 11(1999)-193232, using 3-hydroxymethyl-1-benzylpyrrolidine [taught in Japan Kokai (laid-open) Hei 4(1992)-112868]] and (2R)-1-{(2S,4R)-4-(tert-butoxy)-1-(3,3,3-triphenylpropanoyl)pyrrolidin-2-yl}carbonyl-pyrrolidine-2-carboxylic acid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06809108B1 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-bec0cd5890bc44568b80a3f430664f9c |
| 출처 메모 | uspto-grants-2004_10 |