참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| 반응물 | 4-Methoxybenzenecarbothioamide | HCID 736827 | — |
| 반응물 | Methyl 4-bromo-3-oxopentanoate | HCID 9815681 | — |
| 반응물 | 2-[2-(4-Methoxy-phenyl)-5-methyl-thiazol-4-yl]-ethanol | HCID 22647510 | — |
| 반응물 | Ethyl 2-ethoxy-3-(4-hydroxy-3-methylphenyl)propanoate | HCID 22708451 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | HCID 68617265 | HCID 68617265 | — |
반응 단계
In analogy to the procedure described in example 1 d], [rac]-2-ethoxy-3-(4-hydroxy-3-methyl-phenyl)-propionic acid ethyl ester (example 4 c]) was reacted with 2-[2-(4-methoxy-phenyl)-5-methyl-thiazol-4-yl]-ethanol (prepared from [rac]-4-bromo-3-oxo-pentanoic acid methyl ester [PCT Int. Appl. (2001), WO 01/79202] and 4-methoxy-thiobenzamide in analogy to the procedures described in examples 12 a] and 12 b]) in tetrahydrofuran in the presence of triphenylphosphine and DEAD (diethyl azodicarboxylate) to yield [rac]-2-ethoxy-3-(4-{2-[2-(4-methoxy-phenyl)-5-methyl-thiazol-4-yl]-ethoxy}-3-methyl-phenyl)-propionic acid ethyl ester, which was further saponified in analogy to the procedure described in example 4 e], to yield [rac]-2-ethoxy-3-(4-{2-[2-(4-methoxy-phenyl)-5-methyl-thiazol-4-yl]-ethoxy}-3-methyl-phenyl)-propionic acid as light yellow gum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06809110B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_10 |
|---|
| ORD ID | ord-612d97f44cc54a4aa0cd882560691e1b |
|---|
| 출처 메모 | uspto-grants-2004_10 |
|---|
