Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N,N',N'-Tetramethylazodicarboxamide → HCID 68617601, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N,N',N'-Tetramethylazodicarboxamide | HCID 4278 | — |
| 반응물 | Ethyl 2-chloroacetoacetate | HCID 11858 | — |
| 반응물 | Tributylphosphine | HCID 13831 | — |
| 반응물 | 2,4-Dichlorobenzenecarbothioamide | HCID 2734822 | — |
| 반응물 | HCID 22647612 | HCID 22647612 | — |
| 반응물 | [Rac]-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester | HCID 57792490 | — |
| 생성물 | HCID 68617601 | HCID 68617601 | — |
반응 단계
In analogy to the procedure described in example 10 c], [rac]-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid ethyl ester (example 10 b]) was reacted with 2-(2,4-dichloro-phenyl)-5-methoxymethyl-4-methyl-thiazole (prepared from 2,4-dichloro-thiobenzamide and ethyl 2-chloro-acetoacetate in analogy to the procedures described in examples 33 a] and 33 b]) in the presence of tributylphosphine and N,N,N′,N′-tetramethyl azodicarboxamide to yield [rac]-3-{4-[2-(2,4-dichloro-phenyl)-4-methyl-thiazol-5-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid ethyl ester as colorless liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06809110B2 |
| 출처 데이터셋 | uspto-grants-2004_10 |
| ORD ID | ord-aed08a688fce4fbaa82b509456466145 |
| 출처 메모 | uspto-grants-2004_10 |