Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 3,3-Dimethoxypropanoic acid lithium salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Methyl 3,3-dimethoxypropionate | HCID 81924 | — |
| 반응물 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 3,3-Dimethoxypropanoic acid lithium salt | HCID 87665280 | 98.7% |
반응 단계
(Related to methods described in Alabaster, C. T. et. al., J. Med. Chem. 1988, 31, 2048-2056.) 3,3-Dimethoxypropanoic acid methyl ester (14.25 g, 96.2 mmol) in THF (100 mL) was treated with LiOH H2O (2.5 g, 106 mmol) and H2O (2 mL). The mixture was brought to reflux for 4 hours, cooled to room temperature and azeotropically dried from THF (4 times) to provide white solids (13.3 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06605610B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-e18510a797e744ae90bed1c13013668e |
| 출처 메모 | uspto-grants-2003_08 |