Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Pentyn-1-ol → 5-(2,5-Dichlorophenyl)pent-4-yn-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Pentyn-1-ol | HCID 79346 | — |
| 반응물 | 1,4-Dichloro-2-iodobenzene | HCID 122452 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Diethylamine | HCID 8021 | — |
| 생성물 | 5-(2,5-Dichlorophenyl)pent-4-yn-1-ol | HCID 22320759 | — |
반응 단계
A solution of 1,4-dichloro-2-iodobenzene (20.0 g, 73.3 mmol), 4-pentyn-1-ol (6.17 g, 73.3 mmol), bistriphenylphosphine(Pd II) chloride (1.03 g, 1.47 mmol), and copper(I) iodide (0.14 g, 0.733 mmol) in 400 ml of diethylamine was stirred under nitrogen for three days. This was diluted with dichloromethane and the oily layer was adsorbed onto silica gel and eluted with hexanes-ethyl acetate (5:1) to give 5-(2,5-dichlorophenyl)pent-4-yn-1-ol, 13.7 g (82%); NMR (CDCl3) δ 1.9 (m, 2H), 2.6 (t, 2H), 3.85 (t, 2H), 7.2 (dd, 1H), 7.28 (m, 1H), 7.4 (d, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06605628B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-929d5a52771a4fb78e7fade0ed26344a |
| 출처 메모 | uspto-grants-2003_08 |