Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 395624생성일: 2026년 10월 24일
Dimethylformamide → 4-(4-Chlorophenyl)-2-(2-isopropyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole
https://huagongshe.com/ko/reaction/395624
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1H-Imidazole, 2-(1-methylethyl)- | HCID 123457 | — |
| 반응물 | 2-Chloro-4-(4-chlorophenyl)-5-[3-(2-methylphenoxy)propyl]oxazole | HCID 10882967 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 4-(4-Chlorophenyl)-2-(2-isopropyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole | HCID 18174757 | — |
반응 단계
A mixture of 2-chloro-4-(4-chlorophenyl)-5-[3-(2-methylphenoxy)propyl]oxazole (1.00 g), 2-isopropylimidazole (661 mg), potassium carbonate (830 mg) and N,N-dimethylformamide (10 ml) was stirred at 120-130° C. for 1 hour. The reaction mixture was poured into water (100 ml) and extracted with ethyl acetate (10 ml×2). The organic layer was dried over anhydrous magnesium sulfate and then concentrated. The residue was subjected to silica gel column chromatography, and 4-(4-chlorophenyl)-2-(2-isopropyl-1-imidazolyl)-5-[3-(2-methylphenoxy)propyl]oxazole was obtained as an oil (333 mg, 28%) from an ethyl acetate-hexane (1:1, v/v)-eluted fraction.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US06605629B1 |
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| 출처 데이터셋 | uspto-grants-2003_08 |
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| ORD ID | ord-272344a9f1f0468898b6c4935bfa6305 |
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| 출처 메모 | uspto-grants-2003_08 |
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