Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3,5-Dimethylisoxazole-4-isocyanate → HCID 10109195, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3,5-Dimethylisoxazole-4-isocyanate | HCID 2736266 | — |
| 반응물 | 3-Amino-6-chloro-2-hydroxy-benzenesulfonamide | HCID 11368059 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 10109195 | HCID 10109195 | 49% |
반응 단계
Under Ar, a solution of 3-amino-6-chloro-2-hydroxybenzenesulfonamide (50 mg, 0.23 mmol) and 3,5-dimethylisoxazol4-yl isocyanate (31 mg, 0.23 mmol) in 1.0 mL of N,N-dimethyl-formamide was stirred at room temperature for 20 hours. Purification upon Gilson HPLC, eluting with acetonitrile/water (10/90, v/v to 90/10, v/v, over 10 min), gave the desired product (40 mg, 49%). LC-MS (m/z) 361.0 (M+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06608077B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-6457942f5bfa486ab44bb958b4e1db83 |
| 출처 메모 | uspto-grants-2003_08 |