Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Sulfite → 3-Hydroxymethyl-4-(methylsulfonyl)nitrobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Sulfite | HCID 24437 | — |
| 반응물 | m-Chloroperbenzoic acid | HCID 70297 | — |
| 반응물 | 3-Hydroxymethyl-4-(methylthio)nitrobenzene | HCID 22316807 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 3-Hydroxymethyl-4-(methylsulfonyl)nitrobenzene | HCID 22316955 | 67.5% |
반응 단계
To a solution of 3-hydroxymethyl-4-(methylthio)nitrobenzene from step 1 (20 g, 0.10 mol) in CH2Cl2 (500 mL) and MeOH (100 mL), m-CPBA (74 g, 0.30 mol) was added portionwise at 0° C., and the mixture was stirrred for 16 h at room temperature. The mixture was added aqueous Na2SO3 (20 g in 200 mL of water) at 0° C. Organic layer was separated and washed with saturated aqueous NaHCO3 (300 mL), dried over MgSO4, and concentarted in vacuo gave the title compound (15.6 g, 65%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06608095B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-140c39121b1f478c9525ee309be3571e |
| 출처 메모 | uspto-grants-2003_08 |