Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,3-Dimethoxybenzylamine → (2S)-6-[[2-[(2,3-dimethoxyphenyl)methylamino]acetyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,3-Dimethoxybenzylamine | HCID 78106 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Nalpha-isobutyl-Nalpha-(4-methylbenzenesulfonyl)-Nepsilon-iodoacetyl-L-lysine | HCID 86589941 | — |
| 생성물 | (2S)-6-[[2-[(2,3-dimethoxyphenyl)methylamino]acetyl]amino]-2-[isobutyl(p-tolylsulfonyl)amino]hexanoic acid | HCID 508628 | — |
반응 단계
The title compound was prepared from Nα-isobutyl-Nα-(4-methylbenzenesulfonyl)-Nε-iodoacetyl-L-lysine (150 mg, 0.29 mmol, example 105, step B) by following the indications of general procedure H using DIEA (0.14 mL, 0.81 mmol) and 2,3-dimethoxybenzylamine (0.12 mL, 0.81 mmol). The crude material was purified by preparative HPLC. The product was isolated as a solid (25 mg, 16% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06608100B1 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-6680ed7a53714a0ab70fae6605a7bb33 |
| 출처 메모 | uspto-grants-2003_08 |