Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl Acetoacetate → 3-Allyl-6-methyluracil
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl Acetoacetate | HCID 8868 | — |
| 반응물 | Allylurea | HCID 11181 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 촉매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 3-Allyl-6-methyluracil | HCID 13602047 | — |
반응 단계
To allylurea (25 g, 0.25 mol) in ethanol (10 mL) was added ethyl acetoacetate (31.86 mL, 0.25 mol) and 10 drops conc. HCl. After 12 days at room temperature, concentration gave an oil which was dissolved in MeOH. KOH (22.5 g, 0.34 mol) was added and the solution refluxed for 1 hour. After neutralization, the resulting solid 1 was collected. Yield 2.7 g (7%). NMR (CDCl3) δ: 2.16 (3H, s), 4.52 (2H, d), 5.18 (1H, d), 5.23 (1H, d), 5.60 (1H, s), 5.82-5.93 (1H, m), 10.3 (1H, s).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06608197B2 |
| 출처 데이터셋 | uspto-grants-2003_08 |
| ORD ID | ord-0b659837c93541b1a1830af60c6126e1 |
| 출처 메모 | uspto-grants-2003_08 |